The free event will take place June 1 on the school's football field with gates opening at 6 p.m. and the screening beginning at dusk.
There will be food trucks, student-run booths, raffles and photo opportunities with Gunther the Gondolier. Organizers are suggesting that attendees come in their best 50s outfits with poodle skirts and leather jackets welcome.
The event will have festival seating and people should bring their own blankets and chairs.
Donations will be accepted for the Venice High School Alumni Association, which benefits the school and the alumni scholarship fund.
Two pairs of Grease-Sing-A-Long tickets for an event at the Hollywood Bowl in July also will be raffled off and the winner must be present to claim the prize.
The 1978 film starring John Travolta as badboy Danny Zuko and Olivia Newton-John as good girl Sandy Olsson was adored by the public and critics and its soundtrack was the second-best selling album that year.
This is the second Grease-Sing-A-Long at Venice High after one was held last year during the school's centennial celebration. The Fox show "Glee" also filmed a Grease-themed episode last year at the school.
The 1998 film American History X also was filmed at Venice High.